Biohacking Alzheimers, Age Reversal, Young Blood, Stem Cells, Exosomes & More!

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Anti-aging, Podcast

You've no doubt heard of it by now…

In an attempt to live longer, some anti-aging enthusiasts are getting themselves injected with the blood of young humans, via a process deemed: plasmapheresis.

This podcast is about several age reversal therapies. It's also about biohacking Alzheimers. It's about all these therapies (senolytics, exosomes, gdf-11, etc) that scientists have been talking about for age reversal as well as biological aging clocks and biomarkers to measure them. You'll learn about ways that you can biohack Alzheimer's disease, how to measure your biological age, how to reverse aging, what the biggest obstacle to age reversal is, how to get more involved in the anti-aging community and more.

About the Guests

Mark Urdahl is a technology entrepreneur from the Silicon Valley. He has numerous patents and has worked in big data. He began his career at IBM's medical instruments subsidiary that pioneered plasmaphoresis. Mark founded the Youngblood Institute to advance new uses for well established therapeutic plasma exchange therapies which have recently evidenced a previously undocumented potential to rejuvenate the body's own stem cells, restore aging immune systems, and prevent the onset of many age-related disease condition, so that we might live healthy as we age and ultimately live longer lives.

 

Tom Ingoglia first appeared on this podcast in the episode “The Next Big Anti-Aging Drug: Everything You Need To Know About “NAD”.”  As you learn in that episode, Tom is a private investor with a master’s degree in finance. In the midst of trading, investing in technology and developing real estate in Costa Rica, Tom became very sick. He was initially prescribed antibiotics, suffered from an adverse reaction and was told that he’d have stomach problems for the rest of his life. In the years that followed, Tom also developed severe food allergies. His symptoms worsened, and he next began dealing with insomnia, anxiety, muscle pain, tendinopathies, joint pain, chronic fatigue syndrome, altered and clouded cognition and headaches. He finally had a mental breakdown in 2008. After a prolonged period of taking antibiotics, Tom began experiencing tendonitis throughout his fingers, hands, wrists and ankles and feet, so he started taking pain medications to relieve this pain. He had to give up his career in trading because his sole focus for the next eight years would be on finding a cure to his growing symptoms.

His life consisted of working with physical therapists, going to the gym, going to new doctors, and trying new foods to see if it would help. Throughout Tom’s eight-year battle, he was prescribed consistently and persistently more medication. For six years, he was taking excessive amounts of Hydrocodone and Tramadol every day. Tom became obsessed with researching symptoms and treatments and learned about the NAD+ treatment. He visited a clinic, and on Day 7 of his treatment, “It hit me. I started feeling better. I felt amazing. There was a calm that came over me. I felt safe. I just had no cravings for drugs or pain meds. There was no need for them. I just didn’t have the excruciating pain that I had before. I felt eight years of pain melting away.” Tom has nearly fully recovered, using related treatments to NAD+, and has engaged two cofounders to assist him in building out a facility to help bring this treatment to others in similar situations.

In my conversation with Mark and Tom, you'll discover:

-The history of The Young Blood Institute and how “heterochronic plasma exchange” works…16:00

  • Heterochronic plasma means simply removing old plasma and replacing it with “young” plasma.
  • Others are experimenting with this concept.
  • What Mark does is different from a plasma “infusion.”
  • Plasma is approximately half of our blood volume. 
  • Mark began with IBM Biomedical Systems, who had invented what we now call the “blood cell processor.”

The intricate means of testing used on mice…22:15

  • Basically creating “siamese twins” with mice by stitching them together.
  • Similar procedures have been conducted on humans for over 50 years.
  • Mark wanted to recruit the best medical professionals to the Young Blood Institute. Many of them have been doing it for 30-40 years.

What, if any, are the risks of these plasma exchanges…29:10

  • Roughly a 4% risk of a transfusion reaction, which is akin to what you might experience donating blood.
  • One of the safer procedures in the medical field today.
  • You go through 6 exchanges as part of a protocol.

-The network of doctors that Mark and Tom have built to do a plasma exchange…32:42

  • There are medical professionals all over the U.S. that can do the procedure.
  • Submit an inquiry on the Young Blood Institute website to find a doctor that is near you.

-What anti-aging biomarkers Mark is tracking at the Young Blood Institute…34:51

  • They have more technology testing capability than Stanford, Johns Hopkins and Harvard combined.
  • Key technology: time of flight mass cytometry. Single cell proteionomics.
  • They are trying to develop early detection biomarkers that enables them to prevent the onset of diseases before they become significant.

-The lowest hanging fruit for people to track…46:15

  • The YBI's concern is the function of the body, rather than the age.
  • Your cells are not aware of your “age”.

-What a biological aging clock is…50:20

  • Zymo is a lab that has worked with Steven Horvath. Zymo DNA Methylation Aging Clock
  • Looked at DNA, and seen a pattern from methyl groups attached to certain parts of the genome.

-How can we track biological aging, or slow down our biological aging clock?…52:30

  • Inflammatory markers, heart age, brain age, lung age, skin elasticity.

-The anti-aging booth that Mark and Tom will be operating at a conference called RAAD Fest…54:45

  • Revolution Against Aging and Death
  • Want to have a contest where people calculate their age, and track their progress.
  • Mark and Tom have one of the largest booths at the conference.

-Whether NAD actually gets absorbed into a cell via injections or IV…1:00:30

  • How does Ben feel with an injection? Answer: Incredible.
  • Tom doesn't recommend the injection due to the level of discomfort.

-Why compounded formulas such as glutathione and Vitamin B could be taken off the market soon…1:07:30

  • There's a review similar to a court hearing, where people argue for and against glutathione.
  • Taken off the market for compounding pharmacies.
  • Tom “has his own reasons” for why this could be deemed unsafe.
  • Core problem: the vitamins don't have any intellectual property. Could affect the costs of healthcare.

-How to use technologies such as Vielight and exosomes to address Alzheimer's…1:14:30

  • Alzheimers is a $500 billion industry; the 6th leading cause of death.
  • A Vielight is basically a laser light for your nose and head; photobiomodulation on your skull.

-What GDF11 mRNA is and how it works to improve hearing, smell and sight…1:25:30

  • GDF11 is a DNA repair molecule; makes stem cells active again.
  • Patients see improvements in sex drive, vision, smell, hearing, etc.
  • Legal hurdles to being able to administer it.
  • “Unofficial” results are very positive.

-How senolytics works as a therapy for aging and Alzheimer's, and the importance of quercetin and tocotrienols…1:33:45

  • Describes small molecules that lead to the death of “zombie” cells that don't help the rest of your body.
  • Life Extension article “Natural Compounds that Remove Aging Cells”

-And much more…

Click here for the full written transcript of this podcast episode.

Resources from this episode: 

The NAD Treatment Center

NAD conference

Brain Research Center

The Revolutionary RX Podcast

Beyond NAD Conference – Use discount code “BenlovesNAD” at check out

Connexin 43 hemi channels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells

3T3 L1 Cell Line from mouse

PRESERVING PATIENT ACCESS TO COMPOUNDED MEDICATIONS H.R. 2871

Bulk Drug Substances Nominated for Use in Compounding Under Section 503B of the Federal Food, Drug, and Cosmetic Act

Forecasting the global burden of Alzheimer’s disease

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models

Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss.

Nicotinamide restores cognition in AD transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau

Dr Nady Braidy

Alzheimer’s Disease Statistics

The Bredesen Protocol

-Book:  The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline by Dr. Dale Bredesen

The Vielight

-Exosomes Podcast: The Single, Most Comprehensive Stem Cell Procedure Known To Humankind: How A “Full Body Stem Cell & Exosome Makeover” Works.

Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.

Steve Perry's GDF11 Presentation at RAADFest 2017

Stressed, toxic, zombie cells seen for 1st time in Alzheimer's

Tau protein aggregation is associated with cellular senescence in the brain

Quercetin and Tocotrienols – 500-800mg Quercetin and 150mg tocotrienols per day for 3 months

New study on whether NAD is absorbed into cell via IV

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Do you have questions, thoughts or feedback for Tom, Mark or me? Leave your comments below and one of us will reply!

18 thoughts on “Biohacking Alzheimers, Age Reversal, Young Blood, Stem Cells, Exosomes & More!

  1. Marni Harker says:

    Is the blood exchange WADA “legal” ?

  2. Jerry Bailey says:

    Super good podcast, thanks. Quick question, is there any benefit to giving blood on a regular basis for some sort of cellular turnover? As I understand the recovery process, the body replaces the plasma in a couple of days, and at least 4-6 weeks for new red blood cells which come from bone marrow stem cells. I’m wondering about the quality of the stem cell replacement. Are these old-guy stem cells (I’m 50) which simply create old-guy new red blood cells or is there a “new” benefit to any of this process? Nothing really on the www about this process in detail, just the standard promo info to entice blood donation (iron stores, etc.) and anticipate you and your guests might have a deeper perspective on the science. Thanks!

  3. mia says:

    again i wasn’t able to listen to this one or the one on stem cells, some i can listen to on the same computer and some don’t play, i re load etc but nothing happens

  4. Michael rosen says:

    which model of the Vielight do you prefer?

  5. Lucien Burke says:

    Loved the podcast! Didn’t talk much about the mechanisms of why “young blood” or plasma exchange work though, other than “in with the old out with the new” would love to hear more about exactly how this method is working physiologically.

    1. Lucien Burke says:

      I meant “out with the old in with the new” haha!

  6. Dan says:

    Ben love your podcast! My 79 yr old father has been in ICU for 6 weeks due to a reaction to medication given because of delirium experienced after a surgery. Currently his diet is a soy based tube feed with limited nutrients. My concern is nurishing his brain for heeling (omega 3’s, vitamin E , good fats, etc). Do you have any recommended articles to give the medical staff/ dietician to help support my case to them?

    Thanks Dan

    1. I have a few articles/podcasts you could check out: https://bengreenfieldfitness.com/article/brain-ar… https://bengreenfieldfitness.com/article/brain-ar… https://bengreenfieldfitness.com/article/brain-ar… If you prefer a more direct, customized approach, I'd be happy to help you via a personal one-on-one consult. Just go to https://bengreenfieldfitness.com/coaching

  7. Sandra Lee says:

    Hey Ben. Usually I love the podcast. However, this was the first episode that I just couldn’t finish.

    I have concerns about the use of blood products whose origin is uncertain. Human trafficking; disappearance of people, including children; and black market sale of organs, body parts, and now blood products have been increasingly problematic.

    Putting high value on ‘young’ blood products for rejuvenation purposes pushes the demand for these products through the roof.

    I have previously considered non-self sourced stem cells and other tissues utilized in stem cell treatments to be great options. Listening to this episode made me realize that non-self sourced tissues for stem cell treatment are actually just as problematic as are black market organs.

    How do you know that the products being sold to you are actually obtained without killing a person solely for the purpose of obtaining those tissues?

    There may well be absolutely ethical sources out there, and reliable and honest retailers providing them. But how do you know for certain??

    Hey Ben, it’s something worth considering.

    Great podcast. Thank you for all your great work.

    Breathe

    1. The Young Blood Institute has some pretty robust screening mechanisms. I've passed your comment to the Institute as well.

    2. Mark Urdahl says:

      Sandra,

      Thanks for raising an important concern which the largely non-profit blood industry addresses every day with rigorous FDA regulated screening, testing, and safety standards. All donors must be registered and tested; they are known persons, and the vast majority voluntarily donate without compensation.

      4.5 million Americans would die each year without lifesaving blood transfusions. Just one pint of donated blood can help save as many as three people’s lives. Blood is the most precious gift that anyone can give to another person — the gift of life. A blood donation can even save several lives if the blood is separated into its components — red cells, platelets and plasma — which can be used individually for patients with specific conditions.

      Average donation ages vary, but blood has never before been typed by age. At the Young Blood Institute, we study the relatively new possibility of treating age-associated disorders with young blood that may possess rejuvenative or healing properties, as an alternative to drugs and synthetic pharmaceutical products. We meet or exceed all FDA standards for blood products and currently use purified plasma components which, in their preparation, have undergone extensive testing and safety standards developed over many decades. Imagine you or other young people you know could help your parents, grandparents, aunts and uncles overcome or prevent the onset of chronic diseases, Alzheimer’s, and other age-associated disorders with your own donated blood.

      While the Red Cross and other blood banks do a good job with regular donors and blood drives, the blood supply system can always use more blood, particularly certain rare blood types and especially during emergency or natural disaster conditions. Much of today’s medical care depends on a steady supply of blood from healthy donors, many of whom donate several times a year.

      I would encourage you and everyone who follows this podcast to consider donating blood or blood components at your local blood bank. I donate blood myself. It does not take much time, it is much needed, and every little bit helps.

      Mark Urdahl
      Young Blood Institute

  8. Tom Ingoglia says:

    We are here. We have just been slammed with calls with the last conference.

  9. Corey says:

    Hi Ben, I started taking Tru Niagen last month and energy was through the roof the first week. Second week I had some afternoon drowsiness, but wasn’t sure of the cause. I noticed it, but didn’t think much of it. Then I stumbled upon this video by Chris Masterjohn, who I found through you, and it has made me think twice about taking NR. https://chrismasterjohnphd.com/2018/07/26/careful…

    Any thoughts? Perhaps I just need to inject NAD weekly like you? If so, should I do it before or after my Kion Coffee enema? :)

    1. Tom Ingoglia says:

      People respond differently to different things. There are a variety of ways to increase NAD. The NAD iontophoretic patch is really popular right now. It uses a battery. I love subcutaneous. I still think IV is FAR superior to other forms of administration especially to the brain. This is all anecdotal observations. There isn’t a lot of data out there.

  10. Thomas Shepherd says:

    Hi Ben/kion,

    I tried body health essential aminos for 3 months and they always gave me indigestion.

    I would like to try yours if you are satisfaction guaranteed.

    Obviously if your formulation is the same as body health, then that answers the question.

    1. Thomas. SuperEssential Fish Oil is what I recommend and it will be back in stock this Wednesday 9/26/18. Check out the Kion return policy, pretty sure fish oil falls into our money back guaranteed policy. https://getkion.com/shop/body/livingfuel-superess…

  11. Brandon says:

    Yes, I agree. I wanted to hear a strong argument about how exactly NAD can cross the membrane, but that poor Tom guy almost single handedly burried his argument to me.

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